Hypertensive Disorders of Pregnancy
Conditions
Interventions
Low sFlt-1/PIGF ratio group=38:NA
Sponsors
Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences)
Eligibility
Sex/Gender
Female
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Singleton pregnancy; 2. 20 to 41 weeks of gestation; 3. Hospitalized patients diagnosed with hypertensive disorders of pregnancy; 4. Aged >= 18 years old; 5. Underwent simultaneous sFlt-1/PlGF testing; 6. Clinical uncertainty regarding the severity of their disease and likely progression; 7. Provided written informed consent; 8. Underwent fundus photography.
Exclusion criteria
Exclusion criteria: 1. Patients with overt hemolysis, elevated liver enzymes, and low platelet count (HELLP syndrome) or those with fulminant signs and/or symptoms of PE; 2. History of eye surgery, cataract, or severe refractive media opacity; 3. Severe systemic diseases; 4. Severe systemic diseases or severe psychiatric disorders, Major fetal anomalies detected at recruitment; 5. Patients with a high likelihood of being lost to follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Disease progression within 1–4 weeks of sFlt-1/PlGF testing; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of adverse outcomes in mother and infant;The proportion of pregnancies terminated due to hypertension;Usage rate of antihypertensive drugs and glucocorticoids; | — |
Countries
China
Contacts
Public ContactCui Ying
Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences)
Outcome results
None listed