None
Conditions
Interventions
Invasive mechanical ventilation observation group:None
Sponsors
The People’s Hospital of Chongqing Hechuan
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) Age >=18 years old; (2) Has received invasive mechanical ventilation (MV) for more than 48 hours; (3) Evaluated by the clinical team in charge as meeting the conditions for the first spontaneous breathing trial (SBT); (4) The patient or his/her legal representative has signed a written informed consent form.
Exclusion criteria
Exclusion criteria: (1) There are known or clinically suspected neuromuscular diseases that affect diaphragm function; (2) It is known that there is phrenic nerve injury or phrenic paralysis; (3) It is impossible to obtain clear and repeatable ultrasound images of the diaphragm or intercostal muscles; (4) Pregnancy; (5) The researcher believes that the patient has other conditions that make them unsuitable for participating in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The diagnostic accuracy of the DRAI for predicting SBT failure, as measured by the Area Under the Receiver Operating Characteristic Curve (AUC). ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Diagnostic performance at the optimal cut-off: sensitivity, specificity, positive and negative likelihood ratios.;Comparison of diagnostic accuracy: the AUC of DRAI will be compared to that of the RSBI.;Group differences: comparison of DRAI, ?DTF%, and ?TFic% values between the SBT success and failure groups.;Clinical utility outcomes: extubation failure rate, reintubation rate within 48 hours after a successful first SBT, total duration of MV, ventilator-free days at day 28.; | — |
Countries
China
Contacts
Public ContactXianlong Zhou
The People's Hospital of Chongqing Hechuan
Outcome results
None listed