Sensorineural hearing loss
Conditions
Interventions
Experimental group:Combined use of PTMSC exosome tympanic cavity injection with dexamethasone injection solution
Control group:Tympanic cavity injection of dexamethasone injection
Sponsors
Zhujiang Hospital of Southern Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) The subjects voluntarily cooperated with the study and signed the informed consent. (2) Male or female, aged >=18 years; (3) Sudden sensorineural hearing loss with unexplained hearing loss of more than 30 dB for three consecutive frequencies within 72 hours; (4) With or without other treatment, the average pure tone hearing threshold of hearing loss frequency improved less than 15dB, and the average pure tone hearing threshold before treatment was more than 35dBHL; (5) The onset time was <=28 days, and the treatment with conventional corticosteroids (oral or intravenous injection) for more than 3 days was ineffective; Or onset time <=28 days and contraindications to systemic use of glucocorticoids. (6) Acoustic neuroma was excluded by magnetic resonance imaging (MRI), and no definite etiology (including systemic or local factors) was found.
Exclusion criteria
Exclusion criteria: (1) Acute or chronic infectious inflammation of the middle ear on the affected side, tympanic membrane perforation, tympanic effusion, or cholesteatoma of the middle ear; (2) Women who are pregnant or breastfeeding, or who plan to become pregnant during the study period; (3)Other circumstances deemed ineligible for inclusion by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pure-tone audiometry; | — |
Countries
China
Contacts
Public ContactZhang Hongzheng
Zhujiang Hospital of Southern Medical University
Outcome results
None listed