General Functional Domain
Conditions
Interventions
Group O(oliceridine group):oliceridine was administered intravenously at an initial dose of 70ug/kg.If the cardiovascular response to intubation was negative,the dose was deemed to be effective,and th
If the cardiovascular response is positive,it is considered a failure, and the dose of the next child is increased by 0.05ml/kg.
Group S(sufentanil group):Sufentanil was administered intravenously at an initial dose of 0.3 ug/kg. If the cardiovascular response to intubation was negative, the dose was deemed to be effective, an
If the cardiovascular response is positive, it is considered a failure, and the dose of the next child is increased by 0.05 ml/kg.
Sponsors
Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
1 Years to 12 Years
Inclusion criteria
Inclusion criteria: 1.Age 1-12 years; 2.Gender not restricted; 3.Children undergoing general anesthesia with endotracheal intubation; 4.ASA classification grade I-II; 5. BMI18-27 kg/m^2.
Exclusion criteria
Exclusion criteria: 1.Preoperative symptoms of nausea and vomiting; 2.Children who have already been administered sedative medications prior to surgery; 3.Children with severe malnutrition; 4.Children with a history of anesthesia within 7 days; 5.Children who are allergic to anesthetic drugs such as oliceridine remimazolam ,sevoflurane ,rocuronium bromide; 6.Children suspected of having difficult mask ventilation or difficult tracheal intubation; 7.Severe combined cardiopulmonary diseases,neurological disorders,or significant abnormalities in liver and kidney function 8.Children on long-term opioid therapy; 9.The family members refused to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ED90 of oliceridine inhibiting Cardiovascular Response to Endotracheal Intubation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of respiratory depression;Extubation time; | — |
Countries
China
Contacts
Public ContactLiQunCheng
Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine
Outcome results
None listed