Study on the Rehabilitation Efficacy and Bidirectional Regulation Mechanism of Brain-Spinal Network with Dual-Target rTMS at the Paracentral Lobule and Lumbosacral Enlargement for Spinal Cord Injury (SCI)

A Study on the Reconstruction of Brain-Spinal Cord Bidirectional Network Circuits and Rehabilitation Efficacy through Dual-Target rTMS of SMA and the Lumbosacral Enlargement in iSCI Patients

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2500115749

Enrollment

Unknown

Registered

2025-12-30

Start date

2026-01-11

Completion date

Unknown

Last updated

2026-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Spinal Cord Injury

Interventions

Paracentral Lobule Single-Target Group:Patients in this group will receive rTMS stimulation targeting only the paracentral lobule , with no stimulation applied to the lumbosacral enlargement region.lu

Lumbosacral Enlargement Single-Target Group:Patients in this group will receive rTMS stimulation targeting only the lumbosacral enlargement, without any stimulation applied to the PCL (paracentral lob

Combined Treatment Group:Patients in this group will receive rTMS stimulation targeting both the paracentral lobule and the lumbosacral enlargement.

Eligibility

Sex/Gender

All

Age

14 Years to 80 Years

Inclusion criteria

Inclusion criteria: Age 15 years or older, incomplete spinal cord injury (SCI) (American Spinal Injury Association (ASIA) Impairment Scale (AIS) grade B to D), and disease duration ranging from 15 days to 1 year.

Exclusion criteria

Exclusion criteria: Subjects with ASIA grade E (complete spinal cord injury) and severe cognitive impairment; other exclusion criteria relate to contraindications of rTMS, such as psychiatric disorders, epilepsy, or pregnancy.

Design outcomes

Primary

Measure	Time frame
American Spinal Injury Association (ASIA) Impairment Scale;Lower Extremity Motor Score;	—

Secondary

Measure	Time frame
Neurogenic Bladder Symptom Score;Functional Independence Measure;Functional Near-Infrared Spectroscopy (fNIRS);	—

Countries

China

Contacts

Public ContactWang Benguo

Longgang District People's Hospital, Shenzhen City, Guangdong Province

18760350279@163.com+86 187 6035 0279

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026