FindTrial
Sign In

Mechanistic Study of the Rare Coexistence of Two Functional Tumors in the Ipsilateral Adrenal Gland

Mechanistic Insights into the Rare Coexistence of Ipsilateral Adrenal Pheochromocytoma and Aldosterone-Producing Nodule

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500115744
Enrollment
Unknown
Registered
2025-12-30
Start date
2025-12-30
Completion date
Unknown
Last updated
2026-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pheochromocytoma (PHEO) coexisting ipsilaterally with primary aldosteronism (PA)

Interventions

Case group:N/A

Sponsors

Fuzhou University Affiliated Provincial Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1.Adrenalectomy has been completed; 2.Preoperative diagnosis was primary aldosteronism; 3.Postoperative pathology indicated coexistence of ipsilateral adrenal pheochromocytoma and aldosterone-producing nodule; 4.Somatic VHL mutation has been detected in the pheochromocytoma tissue; 5.Patient provided informed consent.

Exclusion criteria

Exclusion criteria: 1.Postoperative tissue quality does not meet the requirements for analysis; 2.No valid pathological regions are available for laser microdissection or multi-omics research; 3.Patient refused to sign or withdrew informed consent.

Design outcomes

Primary

MeasureTime frame
Regional mutational profile and variant allele frequency;Spatial expression and gradient of key proteins;—

Secondary

MeasureTime frame
Spatial correlation indices;Changes in CYP11B2 mRNA/protein expression;—

Countries

China

Contacts

Public ContactWei Lin

Fuzhou University Affiliated Provincial Hospital

caolalin0929@163.com+86 591 8821 6238

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026