Acute Respiratory Failure
Conditions
Interventions
HFNC+iNO Group:Inhaled Nitric Oxide Combined with High-Flow Nasal Cannula Oxygen Therapy
Sponsors
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age >= 18 years old; 2.Sign the informed consent form; 3.P/F= 24 hours.
Exclusion criteria
Exclusion criteria: 1.Known pregnancy; 2.A history of cerebral hemorrhage within the past six months, or circulatory instability caused by active bleeding; 3.Large - volume pleural effusion without drainage, and tension pneumothorax; 4.Refractory shock; 5.Acquired immunodeficiency syndrome (HIV); 6.Congenital methemoglobinemia; 7.Severe hypoplastic left heart syndrome, life - threatening congenital defects, and congestive heart failure.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28-day invasive mechanical ventilation rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Index of oxygenation, P/F;Region of Interest (ROI);Arterial partial pressure of carbon dioxide, PaCO2;Platelet Aggregation Rate;Soluble intercellular adhesion molecule-1;End-expiratory lung impedance (EELI);Renal Resistive Index (RRI);Global Inhomogeneity(GI);Tidal impedance variation (TIV);P-Selectin;Local over - expansion/collapse (ODCL);Arterial partial pressure of oxygen, PaO2;Activated protein C; | — |
Countries
China
Contacts
Public ContactHongping Qu
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Outcome results
None listed