Primsry aldosteronism
Conditions
Interventions
Observation group:N/A
Sponsors
Xiangya Hospital, Central South University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Aged over 18 years, regardless of gender; 2.Voluntarily agree to participate in this study and sign an informed consent form; 3.Positive PA screening, defined as an upright plasma aldosterone-to-renin ratio (ARR) >=20 (pg/ml)/(µIU/ml) or ARR >=30 (ng/dL)/(ng/ml/hr), with at least one confirmatory test being positive (plasma aldosterone >=110 pg/ml after captopril suppression test (CCT) or plasma aldosterone >=100 pg/ml after seated saline infusion test (SIT)). 4.Subtype diagnosis: UPA (meets any of the following criteria): AVS indicates unilateral lesion; Positive visual imaging on 68Ga-Pentixafor PET/CT, with SUVmax>=7.65 or LCR >=1.60 or LLR >=3.36; Postoperative pathology consistent with UPA HISTALDO classification. BPA (meets any of the following criteria): AVS indicates bilateral lesions; Negative or mildly increased uptake on 68Ga-Pentixafor PET/CT, with SUVmax <7.65, LCR <1.60, and LLR <3.36.
Exclusion criteria
Exclusion criteria: 1.Refusal to participate in the trial, or inability of the patient or close relatives to understand or sign the informed consent form. 2.Coexistence of other common types of secondary hypertension, such as renal artery stenosis, renal parenchymal hypertension, pheochromocytoma, hypercortisolism, etc. 3.Coexistence of malignant tumors or severe cardiac, pulmonary, renal, or hepatic dysfunction. 4.Women who are pregnant or breastfeeding, those planning to become pregnant during the trial period, and women at high risk of pregnancy without taking any contraceptive measures.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Accuracy of the prediction model for PA subtype diagnosis;Accuracy of the prognostic model;Proportion of clinical complete remission; | — |
Secondary
| Measure | Time frame |
|---|---|
| Percentage of biochemical complete remission; | — |
Countries
China
Contacts
Public ContactLuo Xianghang / Jiang Tiejian
Xiangya Hospital, Central South University
Outcome results
None listed