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Does dexmedetomidine affect the long-term prognosis of colorectal cancer patients by improving the inflammatory state?

The influence of dexmedetomidine on the long-term prognosis of systemic inflammatory colorectal cancer patients and its modifying effect on the inflammatory state: A retrospective cohort study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500115714
Enrollment
Unknown
Registered
2025-12-30
Start date
2025-12-31
Completion date
Unknown
Last updated
2026-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Primary colorectal cancer

Interventions

Colorectal Cancer Cohort:None

Sponsors

chongqing university cancer hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1.Age >= 18 years; 2.Colorectal cancer (CRC) diagnosed by pathology; 3.Systemic inflammatory state can be determined;

Exclusion criteria

Exclusion criteria: 1. Death within 30 days of diagnosis due to non-cancer-related causes (e.g., trauma, suicide, homicide); 2. Concurrent presence of significant immunological confounding factors; 3. Critical data missing: inability to confirm DEX exposure status; or complete absence of inflammatory markers within the specified time window; or survival outcomes entirely unavailable; 4. Concurrent other malignant tumours; 5. Pregnancy or lactation period;

Design outcomes

Primary

MeasureTime frame
Overall survival (OS);

Secondary

MeasureTime frame
Days of mechanical ventilation;The incidence of sepsis;Symptomatic bradycardia;The occurrence and duration of delirium;30-day / 90-day all-cause mortality;Clinically significant hypotension;Admission to the ICU;Disease-free survival (DFS);1-year Overall Survival;Cancer-Specific Survival, CSS);Changes in immune function;3-year Overall Survival;

Countries

China

Contacts

Public ContactJiaxi Tang

chongqing university cancer hospital

tangjiaxi1029@126.com+86 23 6507 5601

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026