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Research on the therapeutic and early warning mechanism of zinc finger protein ZFP36 in regulating bone lipid balance of bone marrow mesenchymal stem cells and M2 polarization of macrophages in the occurrence and development of osteoporosis

Research on the therapeutic and early warning mechanism of zinc finger protein ZFP36 in regulating bone lipid balance of bone marrow mesenchymal stem cells and M2 polarization of macrophages in the occurrence and development of osteoporosis

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500115693
Enrollment
Unknown
Registered
2025-12-30
Start date
2026-01-01
Completion date
Unknown
Last updated
2026-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoporosis

Interventions

Osteoporosis group:none
Control group:none

Sponsors

Ningbo Medical Centre Lihuili Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1.Clinical patients who have undergone elective hip or knee joint replacement surgery or have visited the orthopedics department of Li Huili Hospital due to traumatic fractures and have agreed to undergo surgery are eligible, regardless of age, gender or weight.

Exclusion criteria

Exclusion criteria: 1. Patients taking medications related to bone health; 2. Patients with bone or muscle tissue lesions or severe infections.

Design outcomes

Primary

MeasureTime frame
ZFP36 expression;Expression of key genes involved in macrophage polarization;Expression of key genes for bone lipid balance;—

Countries

China

Contacts

Public ContactLi Xufeng

Ningbo Medical Centre Lihuili Hospital

lhllixufeng@nbu.edu.cn+86 574 87018701

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026