Mechanistic study on DHCR7-driven cholesterol metabolic reprogramming in ferroptosis regulation during pneumonia development

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2500115688

Enrollment

Unknown

Registered

2025-12-30

Start date

2026-01-01

Completion date

Unknown

Last updated

2026-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pneumonia

Interventions

Healthy control group:No

Mild pneumonia group:No

Severe pneumonia group:No

Eligibility

Sex/Gender

All

Age

1 Years to 14 Years

Inclusion criteria

Inclusion criteria: 1. Age: 1-14 years old; 2. Pediatric patients diagnosed with pneumonia according to the Guidelines for the Management of Community-Acquired Pneumonia in Children (2024 Revised Edition).

Exclusion criteria

Exclusion criteria: 1Children with underlying/chronic medical conditions including: Chronic pulmonary diseases Immunodeficiency disorders Connective tissue diseases Hematologic disorders; 2Cases with incomplete clinical data or who declined to participate in the study.

Design outcomes

Primary

Measure	Time frame
Glutathione Peroxidase 4(GXP4);Acyl-CoA Synthetase Long-Chain Family Member 4(ACSL4);Malondialdehyde(MDA);7-Dehydrocholesterol Reductase(DHCR7);	—

Countries

China

Contacts

Public ContactLuo Lijun

The First Hospital of Jiaxing

18660927939@163.com+86 573 82519999

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026