severely burned patients
Conditions
Interventions
Control group:Conventional fasting and water therapy
Trial group:Leave a nasogastric tube or nasogastric tube in place and continuously pump 5% GNS at a rate of 40ml/h until 48 hours after injury.
Sponsors
The First Affiliated Hospital of Army Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patient enrollment is based on the principle of voluntariness, and an informed consent form must be signed; 2. Thermal burn patients (flame burns or scalds); 3. Aged 18–65 years, both sexes eligible; 4. TBSA >=50%; 5. Admission within 12h after burns.
Exclusion criteria
Exclusion criteria: 1. Discharge within 48h after burns; 2. Patients with gastric ulcer, gastric bleeding, or gastrointestinal perforation; 3. Patients with diabetes mellitus; 4. Acute or chronic hepatic insufficiency (Child–Pugh grade C or above); 5. Severe cardiac insufficiency (left ventricular ejection fraction <=30 %); 6. Pregnant or lactating women; 7. Patients with chronic kidney disease: glomerulonephritis, immune-mediated renal disorders, etc. 8. Patients with psychiatric or severe cognitive disorders (lacking insight or unable to communicate reliably); 9. Patients with malignant tumors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| mobidity of sepsis; | — |
Secondary
| Measure | Time frame |
|---|---|
| DAO?DLC?BT;CRP?PCT?IL-6;mortality within 90d after burns; | — |
Countries
China
Contacts
Public ContactSong Huapei
The First Affiliated Hospital of Army Medical University
Outcome results
None listed