Subthreshold depression
Conditions
Interventions
Active (center-anode) group:The central anodal group receives high-definition transcranial direct current stimulation (HD-tDCS) with the anode placed at Fpz, at 1.5 mA for 20 minutes.
Sham group:The sham group receives HD-tDCS at Fpz with 1.5 mA stimulation for the initial 30 seconds, followed by a reduction to no more than 2 µA for the remainder of the session.
Sponsors
Institute of Psychology, Chinese Academy of Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 21 Years
Inclusion criteria
Inclusion criteria: 1.Conduct the MINI structured interview; currently does not meet ICD-11 diagnostic criteria for major depressive disorder; 2.Sex:male or female; 3.Age:18-21 years; 4.IQ:above 70; 5.No metallic implants in the body, meets functional near-infrared spectroscopy scanning conditions, and is willing to participate; 6.PHQ-9 self-rating scale score higher than 10.
Exclusion criteria
Exclusion criteria: 1.IQ<70. 2.Currently meets Major Depressive Disorder (M.I.N.I.) or is at high suicide risk. 3.History of epilepsy, stroke, traumatic brain injury, or cranial surgery. 4.Neurological disorders. 5.Substance abuse or alcohol dependence. 6.Use of psychotropic medication within the past 8 weeks. 7.Pregnancy. 8.Local scalp lesion/inflammation. 9.Cardiac pacemaker or metallic implants in the body. 10.Unremovable metal devices on the head. 11.Head injury. 12.For individuals with a history of epilepsy/cranial injury/stroke, inclusion is allowed only after careful evaluation even if recovery is self-reported. 13.Uncontrollable body movements (e.g., severe coughing, convulsions). 14.Chronic pain disorders with intake of analgesics such as aspirin or ibuprofen within the past 3 days. 15.Participation in other similar experiments within the past 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in response bias (b') on the Probabilistic Reward Task (PRT) across pre-, mid-, and post-tDCS stages;Change in discriminability (d') on the Probabilistic Reward Task (PRT) across pre-, mid-, and post-tDCS stages;Change in oxyhemoglobin (?HbO) in the ventromedial prefrontal cortex (vmPFC) across pre-, mid-, and post-tDCS stages; | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in reaction time on the Probabilistic Reward Task (PRT) across pre-, mid-, and post-tDCS stages;Change in accuracy on the Probabilistic Reward Task (PRT) across pre-, mid-, and post-tDCS stages; | — |
Countries
China
Contacts
Public ContactHuang Jia
Institute of Psychology, Chinese Academy of Sciences
Outcome results
None listed