chronic post-surgical pain,CPSP
Conditions
Interventions
Teglitide Group:A bolus dose of 0.75 mg tegileridine is diluted to 3 ml, and the postoperative IV-PCA pump is prepared with tegileridine at 0.075 mg/kg diluted to a total volume of 200 ml, with a PCA
Oliceridine Group :A bolus dose of 1.5 mg oliceridine is diluted to 3 ml, and the postoperative IV-PCA pump is prepared with oliceridine at 0.15 mg/kg diluted to a total volume of 200 ml, with a PCA b
Sufentanil Group :A bolus dose of 7.5 µg sufentanil is diluted to 3 ml, and the postoperative IV-PCA pump is prepared with sufentanil at 0.75 µg/kg diluted to a total volume of 200 ml, with a PCA bolu
Sponsors
Central Hospital of Dalian University of Technology (Dalian Municipal Central Hospital)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients aged between 18 and 80 years, ASA anesthesia classification I-III; 2. Patients undergoing elective thoracoscopic surgery under general anesthesia; 3. Body Mass Index (BMI): 18 kg/m^2 - 28 kg/m^2; 4. Participants fully understand the purpose, content, procedures, and risks of this trial, voluntarily participate in the clinical trial, and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Body Mass Index (BMI) 28 kg/m^2; 2. Preoperative moderate to severe liver or kidney dysfunction, or heart failure; 3. Allergy to any of the study drugs; 4. History of analgesic drug abuse; 5. Severe dementia or communication disorders; 6. Patient or family refusal to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| chronic post-surgical pain; | — |
Secondary
| Measure | Time frame |
|---|---|
| Numeric Rating Scale;Incidence of moderate to severe pain;Opioid-Related Adverse Reactions;Quality of Recovery-15, Qor-15;Neuropathic pain three months after surgery;Anxiety situation three months after surgery; | — |
Countries
China
Contacts
Public ContactCongjie Bi
Central Hospital of Dalian University of Technology (Dalian Municipal Central Hospital)
Outcome results
None listed