Effect of bupivacaine liposomal on chronic pain after thoracic surgery
Conditions
Interventions
Group patient controlled analgesia(group P):No
group erector spinae plane block and patient controlled analgesia (group EP):No
group erector spinae plane block(group E):No
Sponsors
The affiliated Suzhou hospital of Nanjing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) The subjects had a full understanding of the purpose and significance of this trial, volunteered to participate in this clinical trial, and signed an informed consent. (2) Patients undergoing elective thoracoscopic surgery under general anesthesia; (3) Age of 18-80 years old, regardless of gender; (4) 18 kg/m^2 <= BMI <=30 kg/m^2; (5) American Society of Anesthesiologists (ASA) grade ?-?.
Exclusion criteria
Exclusion criteria: (1) Allergic to liposomal bupivacaine, bupivacaine hydrochloride, opioids and other components that may be used in the study; (2) Patients with long-term use of narcotic analgesics, sedatives or non-steroidal anti-inflammatory drugs; (3) Patients with systemic hypotension despite the use of vasoactive drugs; (4) Bradycardia, heart rate < 50 beats/min; (5) High degree atrioventricular block without pacemaker implantation; (6) Combined with craniocerebral injury and intracranial hypertension; (7) Patients with severe heart, lung, liver and kidney dysfunction; (8) Patients with a history of allergic diseases, malignant hyperthermia, or epilepsy; (9) Subjects with previous history of mental disorders and cognitive impairment; (10) Disorders of lipid metabolism; (11) Myasthenia gravis patients; (12) Subjects with sensory disorders such as hyperalgesia; (13) History of alcoholism; (14) Any other circumstances in which the participant was judged by the investigator to be ineligible for participation in the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| chronic pain 3 months postoperatively ; | — |
Secondary
| Measure | Time frame |
|---|---|
| NRS scores at rest and after exercise (cough) within 6h, 12h, 24h, 48h and 72h after surgery;Consumption of opioids;The incidence of postoperative pulmonary complications postoperative 48h;The number of times patients pressed the analgesia pump during 24h, 48h and 72h after surgery;Incidence of nausea and vomiting;Sleep quality 24h and 48h after surgery;Serum CRP concentrations before and 48h after surgery;Serum IL-6 concentrations before and 48h after surgery;length stay in hospital; | — |
Countries
China
Contacts
Public ContactHua Li
The affiliated Suzhou hospital of Nanjing Medical University
Outcome results
None listed