Kidney Transplantation
Conditions
Interventions
Renal transplant recipient:Administer sugammadex to reverse neuromuscular blockade
Renal transplant donor:Administer sugammadex to reverse neuromuscular blockade
Sponsors
Peking University Third Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Patients classified as ASA physical status I to III, aged between 18 and 65 years, who are scheduled to undergo renal transplantation surgery, along with their living kidney donors;
Exclusion criteria
Exclusion criteria: Patients with known or suspected neuromuscular disorders, a history of malignant hyperthermia, pregnancy, or lactation, as well as those who have received preoperative medications that may affect the pharmacokinetics and pharmacodynamics of rocuronium (such as aminoglycoside antibiotics, diuretics, antiepileptic drugs, and selective serotonin reuptake inhibitors, etc.).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood concentration of sugammadex-rocuronium complex; | — |
Secondary
| Measure | Time frame |
|---|---|
| Plasma concentration of rocuronium;Plasma concentration of sugammadex;Urinary concentration of rocuronium;Urinary concentration of sugammadex;Urinary concentration of the sugammadex-rocuronium complex;Serum creatinine at postoperative days 1;Serum blood urea nitrogen (BUN) at postoperative days 1;Serum ß2-microglobulin at postoperative days 1;Serum creatinine at postoperative days 3;Serum blood urea nitrogen (BUN) at postoperative days 3;Serum ß2-microglobulin at postoperative days 3;Serum creatinine at postoperative days 7;Serum blood urea nitrogen (BUN) at postoperative days 7;Serum ß2-microglobulin at postoperative days 7;Serum creatinine at postoperative days 30;Serum blood urea nitrogen (BUN) at postoperative days 30;Serum ß2-microglobulin at postoperative days 30;Incidence of residual neuromuscular blockade (Train-Of-Four ratio < 0.9) at 1 hour postoperatively; | — |
Countries
China
Contacts
Public ContactXu Mao
Peking University Third Hospital
Outcome results
None listed