Acute Ischemic Stroke
Conditions
Interventions
True EECP treatment group:All enrolled patients received intravenous thrombolysis within 4.5 hours (intravenous alteplase at 0.9 mg/kg). All patients received standard medical therapy for AIS 24 hours
Sham treatment group:All enrolled patients received intravenous thrombolysis within 4.5 hours (intravenous alteplase at 0.9 mg/kg). All patients received standard medical therapy for AIS 24 hours afte
Sponsors
The Second People's Hospital of Hefei
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. The diagnosis of acute ischemic stroke met the criteria of the "Chinese Guidelines for the Diagnosis and Treatment of Acute Ischemic Stroke 2018." 2. All patients were managed through the in-hospital and out-of-hospital green channel protocol in accordance with the National Advanced Stroke Center guidelines, with time points automatically recorded by the system; all patients enrolled in the study provided signed informed consent.
Exclusion criteria
Exclusion criteria: 1. History of cerebrovascular disease, including intracranial aneurysm or arteriovenous malformation, neurosurgical intervention or hemorrhagic stroke, or ischemic stroke within the past 3 months; 2. History of major diseases: cancer, AIDS, severe heart disease (left ventricular ejection fraction =180/100 mmHg); 5. Deep vein thrombosis of the lower extremities or coagulation disorder; 6. mRS score <=2 after intravenous thrombolysis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| mRS score;Mortality;Mean flow velocities of the bilateral anterior, middle, and posterior cerebral arteries, and vertebral-basilar arteries before and after treatment;NIHSS and Barthel Index at discharge and at 90 days; | — |
Secondary
| Measure | Time frame |
|---|---|
| Laboratory parameters (including total cholesterol [TC], triglycerides [TG], high-density lipoprotein cholesterol [HDL-C], low-density lipoprotein cholesterol [LDL-C], blood glucose, homocysteine [Hcy], ß2-microglobulin, high-sensitivity C-reactive protein [hs-CRP], neutrophil percentage, and platelet count [PLT]).; | — |
Countries
China
Contacts
Public ContactWang Long
The Second People's Hospital of Hefei
Outcome results
None listed