Acne
Conditions
Interventions
Control Group :Apply the Lactobacillus reuteri cream to the acne lesions once daily for 2 weeks.
Experimental Group:Apply the MPN-coated engineered Lactobacillus reuteri cream to the acne lesions once daily for 2 weeks.
Positive Control Group:Apply 0.1% tretinoin cream to the acne lesions once daily for 2 weeks.
Placebo Group:Apply petrolatum-glycerin cream to the acne lesions once daily for 2 weeks.
Sponsors
Shenzhen People’s Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 33 Years
Inclusion criteria
Inclusion criteria: 1.Patients who meet the diagnostic criteria for acne (confirmed by medical history, clinical manifestations and dermoscopy) and are at stages I to III of the Modified International Classification System. 2. Informed consent and voluntary participation of the patient; 3. Sign the informed consent form; 4. Aged between 18 and 33, with general good health condition; 5. The number of inflammatory lesions exceeds 9.
Exclusion criteria
Exclusion criteria: 1.Have used antibiotics within 1 month before the study start. 2.Have used systemic retinoid therapy within 3 months before the study start. 3.Have undergone any other acne treatment within 1 month before the study start. 4.Have any other condition that the investigator considers would make participation unsuitable (e.g., deemed unreliable, non-compliant, or unable to comprehend the study assessments).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage change in acne count at Week 8 relative to the baseline.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Percentage change in the number of inflammatory acne lesions at Week 8 relative to the baseline;Percentage change in the number of non-inflammatory acne lesions at Week 8 relative to the baseline; Changes in the relative abundance of Propionibacterium, Lactobacillus, and Staphylococcus in acne-prone skin from baseline to Week 8; | — |
Countries
China
Contacts
Public ContactJianglin Zhang
Shenzhen People’s Hospital (The First Affiliated Hospital, Southern University of Science and
Outcome results
None listed