Stroke
Conditions
Interventions
Active S2-M1 ccPAS group:The stimulation targets for S2 and M1 were determined based on the relative positions of the cap electrodes over the corresponding brain regions, identified through visual obs
sham S2-M1 ccPAS group:The ccPAS sham stimulation protocol was set up identically to the experimental group, except that the coil was held at a 90° angle to the head, with only one edge placed against
Sponsors
Shanghai Guanghua Hospital of Integrative Medicine
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Healthy adults aged 40-80 years with an educational level of junior high school or above; 2. First-ever stroke with a disease duration within 1 year; 3. Stroke lesion located in a unilateral cerebral hemisphere or the brainstem, presenting with unilateral hemiplegia; 4. Patients with stable vital signs, clear consciousness, and able to cooperate with relevant examinations and treatments; 5. Presence of unilateral upper limb motor dysfunction, with upper limb function at Brunnstrom stage >= II; 6. Patients or their guardians voluntarily agree to participate in and cooperate with this study and have signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Any contraindications to transcranial magnetic stimulation, such as the presence of metallic implants, pacemakers, or other foreign objects in the body; 2. Transient ischemic attack, recurrent stroke, primary or secondary intracerebral hematoma, subarachnoid hemorrhage, or subdural/epidural hematoma; 3. Lesions involving the stimulation target sites (M1 hand area, S2 region); 4. Severe impairment of consciousness or communication (e.g., severe visual, hearing, speech, or cognitive impairments); 5. History of psychiatric disorders, epilepsy, or current use of antiepileptic therapy; 6. Severe visceral diseases affecting the liver, lungs, heart, kidneys, or other organs; 7. History of substance addiction related to drugs, alcohol, tobacco, or other addictive substances; 8. Other conditions that may cause motor dysfunction, such as Parkinson's disease, peripheral neuropathy, brain tumors, abscesses, or spinal cord diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fugl-Meyer assessment of the upper extremity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Brunnstrom Motor Function Staging Assessment for Hemiplegia;Wolf motor function test, WMFT;Modified Barthel Index;Stroke Specific Quality of Life;FMRI indices; | — |
Countries
China
Contacts
Public ContactLu Hongyuan
Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine
Outcome results
None listed