Effective dose
Conditions
Interventions
High-anxiety group:Using a modified Dixon up-and-down method, remimazolam besylate for injection was administered intravenously to induce loss of consciousness.
Low-anxiety group:Using a modified Dixon up-and-down method, remimazolam besylate for injection was administered intravenously to induce loss of consciousness.
Non-anxious group:Using a modified Dixon up-and-down method, remimazolam besylate for injection was administered intravenously to induce loss of consciousness.
Sponsors
The First Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Females aged 20–40 years; 2. American Society of Anesthesiologists (ASA) physical status I–II; 3. Body mass index (BMI) 18–25 kg/m²; 4. Scheduled for hysteroscopy requiring intravenous anesthesia; 5. Signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Allergy to or contraindication for benzodiazepines; 2. Long-term use of sedatives or antidepressants; 3. Severe arrhythmia; 4. Severe organ dysfunction; 5. History of drug or alcohol abuse; 6. Communication barriers or refusal to participate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ED50 and ED95 of remimazolam for loss of consciousness (MOAA/S = 1) induced by remimazolam; | — |
Secondary
| Measure | Time frame |
|---|---|
| Three-minute observation period of vital signs after loss of consciousness induction;On?scene vital signs;hypotension;Sedation induction time;Bradycardia;Respiratory depression;Injection pain;Vital signs at the end of surgery;operative time; | — |
Countries
China
Contacts
Public ContactBin Wang
The First Affiliated Hospital of Chongqing Medical University
Outcome results
None listed