gallbladder disorders
Conditions
Interventions
Experimental group:Propofol combined with esketamine and dexmedetomidine for general anesthesia
Control group:Propofol combined with sufentanil and remifentanil
Sponsors
The First Affiliated Hospital of Xinjiang Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-60 years; 2. ASA physical status I-II, BMI 18.5-30 kg/m²; 3. Scheduled for elective laparoscopic cholecystectomy under general anesthesia; 4. Normal preoperative cognitive function, with adequate communication and comprehension abilities to complete questionnaires; 5. Voluntary participation with signed informed consent from both the patient and family members.
Exclusion criteria
Exclusion criteria: 1 .Patients with severe cardiac, pulmonary, or psychiatric disorders; 2. Patients with hepatic or renal diseases, coagulation dysfunction, history of alcohol or substance abuse, or chronic pain; 3. Patients with bradycardia, atrioventricular block, or elevated intracranial pressure; 4. Allergy to any medication used in the trial; 5. Pregnant or lactating women, or women during menstruation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| QoR-15;Intraoperative hemodynamic parameters and anesthetic drug dosages; | — |
Secondary
| Measure | Time frame |
|---|---|
| Visual Analogue Scale;Postoperative recovery of gastrointestinal function; | — |
Countries
China
Contacts
Public ContactHai Guo
The First Affiliated Hospital of Xinjiang Medical University
Outcome results
None listed