Study on Fatty Liver Types and Clinical Features in Obese Patients After Laparoscopic Sleeve Gastrectomy

Study on the Types of Fatty Liver Disease and Related Clinical Characteristics in Obese Patients Undergoing Laparoscopic Sleeve Gastrectomy

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2500115618

Enrollment

Unknown

Registered

2025-12-29

Start date

2026-01-01

Completion date

Unknown

Last updated

2026-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Metabolic Syndrome/Metabolic Syndrome/Non-Alcoholic Steatohepatitis

Interventions

Non-alcoholic steatohepatitis (NASH) group:NA

Non-alcoholic fatty liver (NAFL) group:NA

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18–65 years, consistent with the eligible age range for international bariatric and metabolic surgery; 2. Body Mass Index (BMI) >= 35 kg/m², or BMI >= 30 kg/m² complicated with at least one obesity-related metabolic disease (e.g., Type 2 diabetes mellitus [T2DM], hypertension, dyslipidemia, obstructive sleep apnea syndrome [OSAS], etc.); 3.Evaluated and confirmed to meet the surgical indications for Laparoscopic Sleeve Gastrectomy (LSG), and scheduled to undergo elective LSG in our hospital; 4. Preoperative imaging examination (e.g., abdominal ultrasound) or other clinical assessments suggesting the presence of moderate to severe fatty liver disease; 5. No surgical contraindications, and deemed able to tolerate surgery after evaluation by the anesthesiology department; 6. Subjects and their family members are fully informed, have signed the written informed consent form (ICF), and voluntarily agree to undergo intraoperative anterograde sampling and follow-up observations; 7. Able to understand and comply with the research protocol, and willing to accept follow-up and data collection.

Exclusion criteria

Exclusion criteria: 1. Aged 65 years, failing to meet the indications for international bariatric and metabolic surgery; 2. BMI 20 g/day and males > 30 g/day). 10. Other circumstances deemed unsuitable for enrollment by the researchers.

Design outcomes

Primary

Measure	Time frame
Intraoperative Pathological Types of the Liver;	—

Secondary

Measure	Time frame
Postoperative Weight Change (%EWL / BMI Change);Liver Function Parameters (ALT, AST);	—

Countries

China

Contacts

Public ContactLu Mingdong

The Second Affiliated Hospital of Wenzhou Medical University

lumd@wmu.edu.cn+86 577 88002052

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026