VCI (Vascular Cognitive Impairment)
Conditions
Interventions
Control Group:N/A
Sponsors
Shanghai Geriatric Medical Center
Eligibility
Sex/Gender
All
Age
50 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1.Aged 50 to 85 years, regardless of gender; 2.Meet the clinical and neuroimaging diagnostic criteria for VCI, with evidence of cognitive decline in one or more cognitive domains (such as executive function, processing speed, attention, memory, language, or visuospatial ability) confirmed through clinical assessment and neuropsychological testing; 3.Signed informed consent form.
Exclusion criteria
Exclusion criteria: 1.Medical history, clinical, and neuroimaging evidence suggests other potential etiologies for cognitive impairment (such as Alzheimer’s disease, Lewy body dementia, frontotemporal degeneration, normal pressure hydrocephalus, hypothyroidism, vitamin deficiency, severe depression, drug side effects, chronic infections, poisoning, etc.); 2.Presence of untreated pneumothorax, severe respiratory infection or obstructive disease, decompensated heart failure, severe arrhythmia, active bleeding or severe coagulation disorder, uncontrolled epilepsy or high fever, or recent use of chemotherapeutic agents such as bleomycin, cisplatin, or doxorubicin.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment (MoCA) Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mitochondrial Metabolism-related Indicators;OTCA;ADL; | — |
Countries
China
Contacts
Public ContactWeifeng Peng
Shanghai Geriatric Medical Center
Outcome results
None listed