chronic rhinosinusitis,rhinitis,deviated nasal septum
Conditions
Interventions
Non allergic rhinitis (NAR) group:no
Multi disease coexistence (such as eCRSwNP merging AR, DNS merging CRSsNP, etc.) group:no
Allergic rhinitis (AR) group:no
Chronic sinusitis without nasal polyps (CRSsNP) group:no
Chronic sinusitis with nasal polyps (CRSwNP, including eCRSwNP in 80 cases) group:no
Low Deviated Nasal Septum? group:no
High Deviated Nasal Septum? group:no
Sponsors
The First Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Age between 18-60 years old, gender not limited; 2. Having obvious PNDS, such as persistent or recurrent episodes of clearing the throat, coughing, and foreign body sensation in the throat for = 12 weeks, and a VAS score of >= 4 points; 3. Voluntarily participate in this study and sign an informed consent form; 4. Can cooperate to complete nasal swab collection, blood/tissue specimens, clinical evaluation data, and follow-up procedures. For patients with CRS/AR/NAR/DNS single disease, those who are willing to undergo nasal endoscopic surgery need to be newly diagnosed patients; 5. Non surgical patients need to be diagnosed in outpatient settings and have not received systematic treatment, such as nasal saline irrigation, corticosteroid nasal spray, oral/nasal antihistamines, oral anti leukotrienes, allergen specific immunotherapy, biologics (anti IgE/IL-4/IL-5/IL-13), mucoid enhancers, antibiotics, etc.
Exclusion criteria
Exclusion criteria: 1. Patients with the following conditions related to disease and treatment exclusion will not be included: acute upper respiratory tract infection (onset= 10mg/day) within the past 4 weeks; 5.Nasal glucocorticoids (such as mometasone furoate nasal spray) and antihistamines (such as loratadine) were used in the last 2 weeks; 6.Using probiotic preparations (including lactobacilli, bifidobacteria, etc.) or receiving nasal irrigation treatment within the past 3 months; 7.Due to severe organ dysfunction such as heart, liver, and kidney, the patient cannot tolerate the sample collection process. 8. Other exclusion factors exclude those who are unable to cooperate in completing the research process, such as severe cognitive impairment or mental illness (such as schizophrenia); 9. Pregnant or lactating women (to avoid potential risks to the fetus/infant from sample collection); 10. Abnormal nasal structure (such as developmental abnormalities of the nasal turbinate bone) or previous history of nasal surgery (affecting the baseline state of microecology); 11. Allergy to nasal swab material or presence of nasal trauma or bleeding tendency (such as thrombocytopenia); 12. The most common genetic diseases associated with abnormal mucociliary clearance function, such as cystic fibrosis and primary ciliary dyskinesia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| a diversity;ß diversity;serum specific IgE;eosinophils in peripheral blood/nasal mucosal tissue;classification of nasal septum deviation;Lund Kennedy Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| SNOT-22;Hospital Anxiety and Depression Scale (HADS);FeNO;olfactory test; | — |
Countries
China
Contacts
Public ContactJianrong Ge
The First Affiliated Hospital of Soochow University
Outcome results
None listed