Coronary heart disease, heart valve disease
Conditions
Interventions
POD Group:None
Non-POD Group:None
Sponsors
Tianjin First Central Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients undergoing elective cardiac surgery, aged >=65 years, with a FI score >= 0.25 and ASA classification of II-IV.
Exclusion criteria
Exclusion criteria: 1. Accompanied by severe liver and kidney dysfunction; 2. Severe mental illness, recently taking sedatives or antidepressants; 3. Severe visual and hearing impairment or severe disability without self-care ability; 4. Severe cerebrovascular diseases such as intracranial aneurysms, severe stenosis or occlusion of head and neck arteries, vascular cognitive impairment, history of intracranial hemorrhage or traumatic brain injury with sequelae; 5. Preoperative coma, severe dementia or language impairment, unable to cooperate with the study; 6. Preoperative MMSE score<24 points; 7. Aortic related surgery requiring deep hypothermic circulatory arrest; 8. Those who have participated in other clinical trials or refused to sign informed consent forms.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum S100 ß protein;Neuronal specific enolase;miRNA-9-3p;CAM-ICU scale;RASS score; | — |
Secondary
| Measure | Time frame |
|---|---|
| TNF-a;IL-1ß;IL-10;ICU stay time;Ventilator assisted time;Neurological complications;In-hospital Mortality ; | — |
Countries
China
Contacts
Public ContactWeng Yiqi
Tianjin First Central Hospital
Outcome results
None listed