aneurysmal Subarachnoid Hemorrhage
Conditions
Interventions
experimental group:Low-Volume Blood Sampling
control group:standard-Volume Blood Sampling
Sponsors
The First Affiliated Hospital of Army Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients diagnosed with aneurysmal subarachnoid hemorrhage confirmed by CT or MRI, meeting the diagnostic criteria outlined in the Chinese Clinical Management Guidelines for Ruptured Intracranial Aneurysms (2024 edition). 2. Patients who underwent surgical treatment within 24 hours of admission and were expected to stay in the NICU for >=48 hours. 3. Aged between 18 and 80 years (inclusive). 4. Glasgow Coma Scale (GCS) score on admission >3 and =90 mmHg; mean arterial pressure (MAP) >=65 mmHg; no persistent tachycardia (heart rate >100 bpm) or signs of poor peripheral perfusion (e.g., mottled skin, cold and clammy extremities). 6. Patients or their family members fully understood the nature of the study, voluntarily agreed to participate, and provided written informed consent.
Exclusion criteria
Exclusion criteria: 1. Baseline hemoglobin 150×10?/L, or Ret# 40 seconds; 2. Receipt of allogeneic red blood cell transfusion within 48 hours prior to admission. 3. Use of long-acting antiplatelet agents, corticosteroids, immunosuppressants, or ongoing anticoagulant therapy within 7 days prior to admission. 4. Administration of intravenous iron or erythropoiesis-stimulating agents for anemia treatment within 30 days prior to admission. 5. Controlling Nutritional Status (CONUT) score >5 at baseline. 6. Presence of active autoimmune diseases, myelodysplastic syndrome, or other immune system disorders. 7. Severe dysfunction of major organs (e.g., heart, liver, kidneys), active malignancy, or severe systemic infection. 8. Pregnancy, acute thrombosis, active gastrointestinal bleeding, or active bleeding from other sites. 9. Concurrent participation in other clinical studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hemoglobin Drift; | — |
Secondary
| Measure | Time frame |
|---|---|
| Peripheral Circulation;Adverse Neurological Functional Outcome;Incidence of Ischemia-Related Events;Incidence of Specimen Disqualification Due to Coagulation or Hemolysis;Red Blood Cell Transfusion (RBCT);Cerebral Oxygen Saturation; | — |
Countries
China
Contacts
Public ContactTan Binbin
The First Affiliated Hospital of Army Medical University
Outcome results
None listed