None
Conditions
Interventions
Dexmedetomidine group (DEX group):Continuous intravenous infusion of dexmedetomidine 0.5 µ g/kg/h
Physiological saline control (CON group):Continuous intravenous infusion of 0.9% sodium chloride injection saline solution
Sponsors
Jiaxing First Hospital
Eligibility
Sex/Gender
All
Age
45 Years to No maximum
Inclusion criteria
Inclusion criteria: One hundred and ten ASA ?-? patients, aged >=45 yr, undergoing video-assisted thoracoscopic surgery under general anesthesia with tracheal intubation in our hospital, were enrolled. The anesthesia duration was >=1 hour. The study has been reviewed and approved by the hospital ethics committee, and all patients signed the informed consent.
Exclusion criteria
Exclusion criteria: 1) Abnormalities of heart, brain, lung, liver, kidney and blood coagulation (including unstable ischemic heart disease, arrhythmia, complete bundle branch block; Severe bradycardia (heart rate 30kg/m2 5) Patients and their family members refused anesthesia and could not complete the questionnaire.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Detection of hs-cTnT, NT-proBNP, CRP, IL-6 and TNF - a;Conventional echocardiography and examination;General situation analysis;Map, HR at admission, minimum map during operation, extubation time, PACU time, hospitalization days, dosage of remifentanil and propofol, postoperative complications (hypotension, bradycardia, pneumo; | — |
Countries
China
Contacts
Public ContactZhou Juan
Jiaxing First Hospital
Outcome results
None listed