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The Effect of Probiotic Supplementation Combined with Repetitive Transcranial Magnetic Stimulation on Post-Stroke Depression and Its Association with Inflammatory Reduction: A Randomized Controlled Trial

Effect of Probiotic Supplementation Combined with Repetitive Transcranial Magnetic Stimulation on Post-Stroke Depression Under the Brain-Gut Axis Theory

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500115577
Enrollment
Unknown
Registered
2025-12-29
Start date
2026-01-05
Completion date
Unknown
Last updated
2026-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post-stroke Depression

Interventions

Combined Intervention Group:Repetitive transcranial magnetic stimulation combined with probiotic supplementation
Active Control Group:Repetitive transcranial magnetic stimulation combined with placebo

Sponsors

Cangzhou Central Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Patients with cerebral infarction; 2. Clinical diagnosis of depression; 3. Patients voluntarily participated in the study and signed informed consent

Exclusion criteria

Exclusion criteria: 1. Patients with serious heart disease, liver function damage, kidney function damage and other serious organ lesions; 2. Patients undergoing other clinical trials or interventions; 3. Incomplete clinical data.

Design outcomes

Primary

MeasureTime frame
HAMD-17 score;—

Secondary

MeasureTime frame
Barthel Index;MoCA score;Serum IL-6 concentration;—

Countries

China

Contacts

Public ContactYaowen Zhang

Cangzhou Central Hospital

15131728613@163.com+86 151 3172 8613

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026