Septic Shock
Conditions
Interventions
Methylene blue intervention group:Use methylene blue
Saline placebo group:Use saline solution
Sponsors
Ningbo Beilun People’s Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Over 18 years old; 2. Meets the diagnostic criteria for septic shock as defined in sepsis 3.0; 3. Diagnosed with septic shock and started on norepinephrine within 24 hours; 4. The dosage of norepinephrine required to maintain a mean arterial pressure of >=65 mmHg is >=0.5 µg/kg/min.
Exclusion criteria
Exclusion criteria: 1. Women who are pregnant or breastfeeding; 2. Expected survival time < 48 hours; 3. Noradrenaline has been used for more than 24 hours; 4. Patients with concurrent cardiogenic, obstructive, or hypovolemic shock; 5. Individuals allergic to methylene blue components; 6. Patients with glucose-6-phosphate dehydrogenase deficiency; 7. In the past three days, individuals who have suffered from methemoglobinemia or acute cyanide poisoning caused by chemicals such as nitrite, nitrate, aniline, nitrobenzene, trinitrotoluene, benzoquinone, phenylhydrazine, and drugs containing or producing aromatic amines (such as acetanilide, acetaminophen, phenacetin, benzocaine, etc.); 8.The patient or their representative refuses to participate; 9. During the research process, patients who voluntarily discharged themselves, transferred to other hospitals, gave up treatment, or experienced adverse drug reactions, rendering the trial unable to continue; 10. Those with missing clinical data and information.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28-day all-cause mortality after diagnosis of septic shock; | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of norepinephrine administration after diagnosis of septic shock;Mechanical ventilation duration;Total dose of norepinephrine used;CRRT treatment rate;ICU length of stay;The duration of not using norepinephrine within 28 days;total hospital stay; | — |
Countries
China
Contacts
Public ContactHuang Zhiping
Ningbo Beilun People’s Hospital
Outcome results
None listed