Moderate to severe acute respiratory distress syndrome
Conditions
Interventions
Control group:standard of care for ARDS
Sponsors
Southern Medical University Southern Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Voluntary signing of the informed consent form; 2. Age > 18 years old; 3. Diagnosed as moderate to severe ARDS patients requiring endotracheal intubation or not requiring endotracheal intubation, in accordance with the 2023 Global ARDS standards issued by AAJRCCM.
Exclusion criteria
Exclusion criteria: 1. Known to be allergic to iNO 2. Congenital hyperbilirubinemia 3. End-stage chronic lung diseases, including lung malignancies, lung resection, and lung transplantation history 4. Patients with shock or hemodynamic instability at the start of treatment (norepinephrine dose exceeding 0.5 µg/kg/min for 6 hours or more than the equivalent dose of other vasoactive drugs) 5. Measured pulmonary artery systolic pressure (PAP) > 45 mmHg by transthoracic echocardiography-Doppler or mPAP >=25 mmHg determined by right heart catheterization 6. ICU stay/ mechanical ventilation time less than 24 hours 7. Serum creatinine value > 2.5 mg/L (221 mmol/L) 8. Severe bleeding, such as intracranial hemorrhage, intraventricular hemorrhage, pulmonary hemorrhage, or platelet count < 20 x 10^9/L 9. Previously received extracorporeal membrane oxygenation treatment 10. Judged by the investigator to be unsuitable for participation in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28-day all-cause mortality; | — |
Secondary
| Measure | Time frame |
|---|---|
| PaO2 / FiO2 index;Serum creatinine; | — |
Countries
China
Contacts
Public ContactZhenhua Zeng
Southern Medical University Southern Hospital
Outcome results
None listed