Post-spinal anesthesia hypotension
Conditions
Interventions
Room temperature crystalloid group (R group):The up-and-down adjustment method infuses norepinephrine at a constant rate
Isothermal crystalloid group (W group):The up-and-down adjustment method infuses norepinephrine at a constant rate
Sponsors
Wenling Maternal and Child Health Care Hospital
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: ASA I-II, parturients of singleton pregnancy (gestational age >= 37 weeks) undergoing elective cesarean section
Exclusion criteria
Exclusion criteria: ASA >= ?, systolic blood pressure 140 mmHg, height 170 cm, age 40 years, obesity (body mass index >= 40 kg/m²), allergy to norepinephrine, gestational hypertension, diabetes, cardiovascular disease, coagulation disorder, thrombocytopenia, contraindication to spinal anesthesia, placenta previa, rupture of membranes, congenital fetal malformations, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of maternal hypotension during the period from spinal anesthesia to the delivery of the fetus;Fetal umbilical artery blood pH value;The ED50 value of norepinephrine infusion combined with isothermal or room-temperature crystalloid co-loading for preventing hypotension after cesarean section spinal anesthesia; | — |
Secondary
| Measure | Time frame |
|---|---|
| The maternal hemodynamic parameters (blood pressure and heart rate) within 15 minutes after spinal anesthesia;Apgar scores at 1 and 5 minutes after delivery;The incidences of severe maternal hypotension, reactive hypertension, bradycardia, nausea, vomiting, chills, etc. occurred.;The ED95 value of norepinephrine infusion combined with isothermal or room-temperature crystalloid co-loading for preventing hypotension after cesarean section spinal anesthesia; | — |
Countries
China
Contacts
Public ContactZhimin Sheng
Wenling Maternal and Child Health Care Hospital
Outcome results
None listed