Post-PCI treatment of coronary heart disease accompanied by anxiety and depression
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1.Patients with a confirmed diagnosis of CHD who have undergone PCI; 2.Aged between 18 and 75 years, regardless of gender; 3.Classified as moderate or low risk according to exercise rehabilitation risk stratification; 4.Fully conscious, and voluntarily provide written informed consent after being fully informed of the trial procedures; 5.The Psycho-Psychological Self-Assessment Questionnaire meets the following criteria: PHQ9 score of 5-10 or GAD-7 score of 5-15 or PHQ-15 score of 5-15; 6.No mental illness, normal cognitive and communication skills, and good cooperation.
Exclusion criteria
Exclusion criteria: 1.History of coronary artery bypass grafting (CABG); 2.Patients with acute myocardial infarction; 3.Patients with cardiogenic shock, coronary artery disease combined with heart failure NYHA class III-IV, malignant arrhythmias (frequent ventricular premature beat, nonsustained ventricular tachycardia), and severe conduction block requiring pacemaker implantation; 4.Patients with respiratory failure, liver function (ALT, AST higher than twice the normal), renal function creatinine greater than 2 times the normal upper limit, bone marrow immune system disease, and digestive system bleeding; 5.Tumor patients; 6.Patients who are susceptible to allergies or are allergic to test drugs; 7.Severe anxiety, depression, schizophrenia; 8.Previous use of antidepressant anxiety drugs or drug alcohol dependence; 9.Have a history of epilepsy, mental retardation disease; 10.Pregnant or lactating women; 11.Cognitive decline, or disturbance of consciousness; 12.Those who are unable to cooperate with the doctor to complete the test or drop out midway; 13.Refuse to participate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SPPB Strength and Balance Project;five times sit to stand test;60 seconds sitting test;Balance ability of standing on one foot;Cardiac autonomic neuropathy analysis;heart rate variability analysis;change rate in the 12-Item Short Form Health Survey score;improvement rate in self-rated anxiety and depression scale scores;Seattle Angina Questionnaire score;N-terminal pro-B-type natriuretic peptide levels; | — |
Secondary
| Measure | Time frame |
|---|---|
| Fasting blood glucose;lipid profile; | — |
Countries
China
Contacts
Affiliated Hospital of Jining Medical University