cough
Conditions
Interventions
Experimental group (taVNS stimulation group):Routine care
control group (sham stimulation group):Routine care
Sponsors
The first affiliated hostipal of nanchang university
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.PDoC patients (VS/UWS or MCS) diagnosed in accordance with the Chinese expert consensus on chronic consciousness disorder rehabilitation; 2.Age>18 years old; 3.Vital signs are stable. 4.Can accept cough reflex test. 5.The primary caregiver of the patient voluntarily signs an informed consent form.
Exclusion criteria
Exclusion criteria: 1.In the baseline citric acid cough reflex test, the cough threshold concentration is>1000 µ mol/L. 2.Recent (within 4 weeks) severe arrhythmia, frequent epilepsy, or unstable intracranial pressure; 3.Ear skin damage or local infection, obvious intolerance to electrical stimulation; 4.Relying on high-dose sedatives/muscle relaxants to affect reflex assessment; 5.Those who are contraindicated to use taVNS devices such as pacemakers/implantable electrical stimulators; 6.Active pulmonary infections require intensified anti infective treatment; 7.Participate in other clinical studies during the same period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| (Natural Cough Threshold,NCT); | — |
Secondary
| Measure | Time frame |
|---|---|
| (Standardized Swallowing Assessment,SSA);(Clinical Pulmonary Infection Score Evaluation, CPIS);(functional near - infrared spectroscopy , fNIRS); | — |
Countries
China
Contacts
Public ContactLi Liqun
The first affiliated hostipal of nanchang university
Outcome results
None listed