malnutrition after gastrointestinal reconstruction surgery
Conditions
Interventions
Midgut-tube Washed Microbiota Transplantation Group:Midgut-tube Washed Microbiota Transplantation
Colon-TET Washed Microbiota Transplantation Group:Colon-TET Washed Microbiota Transplantation
Sponsors
The Second Affiliated Hospital of Hainan Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Aged between 18 and 70 years, inclusive, regardless of sex 2.Having undergone gastroduodenal reconstruction surgery (Billroth II or Roux-en-Y procedure) at least six months prior 3.Experiencing a weight loss of >5% compared to the post-operative baseline weight (6 months after surgery) over the past six months without intentional dieting, or for patients with a baseline BMI 2% over the past six months 4.An NRS2002 score of >=3 points 5.Failure to respond to conventional nutritional support therapy for >=2 months 6.Ability to provide informed consent.
Exclusion criteria
Exclusion criteria: 1.Expected survival of less than 3 months 2.Edema or ascites resulting from malnutrition 3.Albumin level 2 mg/dL or 177 µmol/L) or abnormal liver function (ALT > 2× upper limit of normal) 13.moderate to severe chronic obstructive pulmonary disease 14.severe hypertension or history of cerebrovascular accident 15.congestive heart failure or unstable angina 16.Patients with food allergies
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical Response Rate; Clinical Remission Rate;Total Lymphocyte Count;High-Sensitivity C-Reactive Protein; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum Albumin;Total Protein;Prealbumin;Hemoglobin;Cholesterol;Transferrin; | — |
Countries
China
Contacts
Public ContactFeihu Bai
The Second Affiliated Hospital of Hainan Medical University
Outcome results
None listed