Alzheimers disease
Conditions
Interventions
EF-guided group:Employing the iTBS paradigm, individualised superficial cortical stimulation targets were calculated using GCA-fMRI. The resting motor threshold was set at 100%. Stimulation duration w
Non-precision group:Using the iTBS paradigm, stimulation targets were selected at random sites within the IPL. Each pulse lasted 2 seconds, with an 8-second inter-pulse interval. Each session comprise
Sponsors
Affiliated Hospital of Hangzhou Normal University
Eligibility
Sex/Gender
All
Age
50 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1.Aged 50-85 years, meeting the 2024 AD diagnostic criteria established by the National Institute on Aging and the Alzheimer's Association. 2.Clinical Dementia Rating (CDR) score of 0.5 to 1. 3.Positive for core AD Class 1 biomarkers. 4.Able to cooperate with multimodal MRI examination. 5.Able to cooperate with TMS treatment. 6.Patient provides informed consent and signs the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Contraindications for TMS intervention and magnetic resonance imaging (e.g., cardiac pacemaker). 2.Comorbid with other severe diseases such as malignant tumors. 3.Cognitive impairment due to other various causes or severe mental illness (24-item HAMD score >35, 14-item HAMA score >29), unable to maintain a sitting position and cooperate with rehabilitation assessment and treatment. 4.History of metal implant surgery. 5.History of epileptic seizures/epilepsy/taking anti-epileptic drugs; Pregnancy. 6.History of cranial surgery. 7.Presence of severe cardiopulmonary dysfunction, extreme debilitation, or other medically unstable conditions.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ADAS-cog14 Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Multimodal MRI metrics; | — |
Countries
China
Contacts
Public ContactWangjinghua
Affiliated Hospital of Hangzhou Normal University
Outcome results
None listed