Schizophrenia
Conditions
Interventions
HC+SMK group:none
SCZ+NSMK group:none
SCZ+SMK group:none
HC+NSMK group:none
Sponsors
Wuxi Mental Health Center
Eligibility
Sex/Gender
Male
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.All participants aged 18-60 years; 2.signed informed consent; 3.schizophrenia group meets DSM-5 diagnostic criteria with stable condition (PANSS total score =10 cigarettes per day for >1 year (FTND>=4); 5.non-smoking groups have no history of smoking; 6.healthy control group has no personal history of mental disorders; 7.all participants have the cognitive ability to complete the experiments (MoCA>=20); Healthy control group: No history of mental illness; smokers matched by smoking amount, non-smokers with no history of smoking.
Exclusion criteria
Exclusion criteria: 1.Current or past diagnosis of bipolar disorder, major depressive disorder (with psychotic features), autism spectrum disorder, or substance-induced psychotic disorder (e.g., drug abuse); 2.Meets criteria for any substance use disorder according to DSM-5 (alcohol, cannabis, etc.), or has engaged in illicit drug use within the past three months (as evidenced by a positive urine test). 3.presence of MRI/EEG contraindications (such as metal implants, claustrophobia); 4.Epilepsy, traumatic brain injury (with loss of consciousness exceeding 30 minutes), brain tumour, history of stroke; 5.pregnant or lactating women; 6.Severe physical illnesses such as uncontrolled hypertension (BP > 160/100 mmHg), recent myocardial infarction (<6 months), advanced cancer; 7.other circumstances deemed by investigators as unsuitable for participation in this study;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Functional MRI data;EEG data;Biological samples; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical assessment; | — |
Countries
China
Contacts
Public ContactXiangjun Zhou
Wuxi Mental Health Center
Outcome results
None listed