schizophrenia
Conditions
Interventions
True stimulation group:The site for stimulating the left DLPFC is located 125 pixels anterior to the sagittal plane of the maximum abductor pollicis brevis stimulation site. A train of 20 pulses of 5
sham stimulation group:The butterfly-shaped coil was placed on the interhemispheric fissure of the top of the brain, with a relatively low stimulation intensity (10% of the resting motor threshold), w
Sponsors
Suzhou Guangji Hospital
Eligibility
Sex/Gender
All
Age
15 Years to 60 Years
Inclusion criteria
Inclusion criteria: The subjects were hospitalized obese schizophrenia patients aged 15-60 years, with a BMI of >=30kg/m^2, a stable weight (+/-5%) for 6 weeks, meeting the ICD-10 diagnostic criteria for schizophrenia, who were in stable condition (PANSS total score <= 60 points), and were able to complete the program.
Exclusion criteria
Exclusion criteria: 1. History of head injury or epilepsy/seizures; 2. pacemakers, in vivo metal implants, and other contraindications to fMRI or rTMS; 3. Use of weight loss drugs or very low-calorie diet, pregnancy or lactation, eating disorders, or substance dependence within the past year; 4. Unstable cardiovascular disease (myocardial infarction or stroke within the last 1 year, heart failure, acute limb ischemia, severe peripheral arterial occlusive disease); 5. other potential causes of obesity (hypothyroidism, Cushing's syndrome, hypogonadism, insulinoma) documented in the medical history or physical examination; 6. Those who are currently using cochlear implants.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in BMI in obese patients with schizophrenia;Changes in resting-state brain function in DLPFC brain regions before and after rTMS treatment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in body weight at baseline examination;Change in average total daily caloric intake;Change in appetite VAS score;Changes in cognitive function; | — |
Countries
China
Contacts
Public ContactGuangya Zhang
Suzhou Guangji Hospital
Outcome results
None listed