postoperative neurocognitive disorder
Conditions
Interventions
the auricular vagal nerve stimulation group:Perioperative auricular vagus nerve stimulation
Sponsors
Jiaxing Second Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: (1) Age >= 65 years; (2) Patients undergoing elective surgery for abdominal malignancy (gastrointestinal tumors); (3) American Society of Anesthesiologists (ASA) Class I-III; (4) Montreal Cognitive Assessment Scale (MoCA) >=23 points.
Exclusion criteria
Exclusion criteria: (1) Have a communication disability (e.g., difficulty in seeing, hearing, speaking); (2) Comorbid or previous central nervous system disorders such as stroke, Alzheimer's disease, and others; (3) Comorbid or former psychosomatic disorders such as depression, mania, anxiety, schizophrenia, and others; (4) Comorbid immune system disorders;Long-term treatment with anti-inflammatory drugs, painkillers, glucocorticoids, and cytotoxic drugs; (5) History of alcoholism, drug abuse, or drug dependence; (6) Skin lesions at the site of electroacupuncture stimulation; (7) Inability to be still during treatment, such as Parkinson's disease, epilepsy, and others; (8) Illiteracy and inability to communicate normally in Chinese. (9) Postoperative hospital stay <7 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative cognitive dysfunction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in perioperative plasma S100ß and IL-6;Changes in postoperative sleep quality and postoperative pain intensity;Postoperative nausea and vomiting,Postoperative delirium; | — |
Countries
China
Contacts
Public ContactJian Lu
Jiaxing Second Hospital
Outcome results
None listed