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Effect of Using Premedication of Pronase With sitting massage on Visualization of the Mucosa Before Gastroscopy: Study Protocol for a Prospective, Single-Center, Randomized Controlled Trial

Effect of Using Premedication of Pronase With sitting massage on Visualization of the Mucosa Before Gastroscopy: Study Protocol for a Prospective, Single-Center, Randomized Controlled Trial

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500115492
Enrollment
Unknown
Registered
2025-12-26
Start date
2025-12-31
Completion date
Unknown
Last updated
2026-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Visibility of the gastric mucosa

Interventions

Seated Activity Method:Thirty to sixty minutes prior to gastroscopy, administer the streptokinase solution orally. Instruct the patient to sit in the waiting area chair, grasp both armrests, and perfo
Seated Abdominal Massage Technique:After taking the streptokinase solution orally 30-60 minutes prior to gastroscopy, instruct the patient to sit in the waiting area chair in an upright or semi-uprigh

Sponsors

The Third People's Hospital of Chengdu
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Able to undergo gastroscopy; 2. Discontinue anticoagulant medications one week prior to endoscopy; 3. Voluntarily participate and provide written informed consent.

Exclusion criteria

Exclusion criteria: 1. Contraindications of EGD; 2. Pregnancy or lactation; 3. Allergic to streptokinase or simethicone; 4. Patients with impaired function of vital organs such as the heart, lungs, and kidneys, or those who cannot tolerate endoscopy and anesthesia; 5. Liver cirrhosis with esophageal and gastric varices; 6. Active gastrointestinal bleeding; 7. History of gastrointestinal surgery; 8. Severe gastric retention; 9. Patients who are unable to cooperate with seated exercises and massage techniques.

Design outcomes

Primary

MeasureTime frame
Visibility of the gastric mucosa;

Secondary

MeasureTime frame
Endoscopy Time;Water consumption for cleaning;Detection rate of microlesions and biopsy rate;Abdominal discomfort;Adverse reactions: Incidence of adverse events such as abdominal pain, bloating, nausea, vomiting, and coughing.;Safety evaluation: Observe and record the patient’s heart rate, blood pressure, pulse, and respiration before and after the procedure. Observe and record whether the patient develops adverse reactions such as rash or pruritus during the trial.;

Countries

China

Contacts

Public ContactJiang Lin

The Third People's Hospital of Chengdu

23963201@qq.com+86 138 8190 4617

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026