Infectious disease
Conditions
Interventions
Pharmaceutical care group:From January to December 2026, pharmacists will closely monitor patients who meet the inclusion and exclusion criteria. Based on conventional therapy, clinical pharmacists ma
timely culture specimens are ensured for patients on VPT combination therapy. Daily assessments of antimicrobial efficacy are performed, and de-escalation or switching to targeted agents is implemente
Historical contr
Sponsors
Nanjing Drum Tower Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 18–80 years who received the VPT regimen for at least 48 h at the participating centers; 2. Expected survival > 72 h; 3. Signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Receipt of two or more ß-lactam agents during the concomitant period; 2. Patients on extracorporeal membrane oxygenation (ECMO); 3. Death within 48 h after initiation of combination antibiotic therapy; 4. Presence of shock or already-established AKI between hospital admission and the start of the target antimicrobial regimen; 5. Obstructive uropathy such as nephrolithiasis; 6. Use of intravenous polymyxins or aminoglycosides during the study follow-up; 7. Creatinine clearance < 30 mL/min; 8. Pregnant patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Drug-related AKI; | — |
Secondary
| Measure | Time frame |
|---|---|
| Severe DRAKI;Any AKI;No-AKI 30 day survival;Clinical cure; | — |
Countries
China
Contacts
Public ContactChen Dayu
Nanjing Drum Tower Hospital
Outcome results
None listed