parturients who are scheduled for elective cesarean delivery
Conditions
Interventions
Normal group 1:Intravenous prophylactic infusion of norepinephrine 0.02 µg/kg/min
Normal group 2:Intravenous prophylactic infusion of norepinephrine 0.03 µg/kg/min
Normal group 3:Intravenous prophylactic infusion of norepinephrine 0.04 µg/kg/min
Normal group 4:Intravenous prophylactic infusion of norepinephrine 0.05 µg/kg/min
Normal group 5:Intravenous prophylactic infusion of norepinephrine 0.06 µg/kg/min
Obesity group 1:Intravenous prophylactic infusion of norepinephrine 0.02 µg/kg/min
Obesity group 2:Intravenous prophylactic infusion of norepinephrine 0.03 µg/kg/min
Obesity group 3:Intravenous prophylactic infusion of norepinephrine 0.04 µg/kg/min
Obesity group 4:Intravenous prophylactic infusion of norepinephrine 0.05 µg/kg/min
Obesity group 5:Intravenous prophylactic infusion of norepinephrine 0.06 µg/kg/min
Sponsors
Women's Hospital School of Medicine Zhejiang University
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: ASA grade II, single pregnancy, gestational age >= 37 weeks, BMI >= 30 kg/m^2, or BMI 18.9–24.9 kg/m^2, women aged 18 to 40 undergoing elective cesarean section, including both obese and normal-weight mothers
Exclusion criteria
Exclusion criteria: 1.The contraindications of spinal and epidural anesthesia ; 2. Active stage of labor; 3. placenta previa or other placental abnormalities; 4. multiple pregnancy; 5. Emergency or immediate cesarean section; 6. History of 3 or more cesarean sections; 7. umbilical cord prolapse; 8. Previous history of hypertension, preeclampsia; 9. Patients with a history of norepinephrine allergy; 10, Patients with any cardiovascular system disease; 11. refuse to sign the informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Whether hypotension occurs between spinal anesthesia and fetal delivery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Neonatal outcome;Maternal hemodynamic changes;Maternal adverse reactions; | — |
Countries
China
Contacts
Public ContactXiaowei Qian
Women's Hospital School of Medicine Zhejiang University
Outcome results
None listed