Acute Ischemic Stroke?(AIS)
Conditions
Interventions
AIS Group:NA
(VRF) Control Group:NA
Sponsors
Rugao People's Hospital
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: AIS Group 1. Age: Patients aged between 40 and 80 years. 2. Diagnosis: Clinically diagnosed with Acute Ischemic Stroke (AIS). 3. Imaging Confirmation: Acute cerebral infarction lesions confirmed by CT or MRI imaging. 4. Timing: Able to undergo the first blood sample collection (T1) within 24 hours of symptom onset. 5. Informed Consent: The patient or their legal guardian has signed the informed consent form. Vascular Risk Factors (VRF) Control Group 1. Matching: Generally matched with the AIS group in terms of age and gender. 2. Key Criteria: Must have at least two vascular risk factors (e.g., hypertension with diabetes mellitus, or hypertension with hyperlipidemia), but no history of stroke or Transient Ischemic Attack (TIA).
Exclusion criteria
Exclusion criteria: 1. Imaging-confirmed Intracranial Hemorrhage: Diagnosis of Intracerebral Hemorrhage (ICH) or Subarachnoid Hemorrhage (SAH) by imaging. 2. Active Infection or Fever: Known active infection upon admission (e.g., pneumonia, urinary tract infection) or body temperature > 38°C. 3. Chronic Inflammatory or Autoimmune Diseases: Known systemic autoimmune diseases or chronic inflammatory conditions (e.g., rheumatoid arthritis, systemic lupus erythematosus). 4. Recent Major Trauma or Surgery: Major surgery or severe trauma within the past 3 months. 5. Immunosuppressant Use: Long-term use of immunosuppressive agents (e.g., glucocorticoids, chemotherapeutic drugs). 6. Hematologic Malignancies: Presence of any hematological malignancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Neurological functional prognosis (Modified Rankin Scale, mRS);NIHSS score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Proportions of peripheral monocyte subsets (classical, intermediate, non-classical);CCR2 MFI on monocytes;HLA-DR MFI on monocytes;CX3CR1 MFI on monocytes;Serum IL-6 levels;Serum CCL2 levels;Serum IL-10 levels; | — |
Countries
China
Contacts
Public ContactLu Jing
Rugao People's Hospital
Outcome results
None listed