Perimenopausal syndrome
Conditions
Interventions
Intravenous administration group:Administration mode of estaketamine
Perineural administration group:Administration mode of estaketamine
Control group: ropivacaine alone:Administration mode of estaketamine
Sponsors
The Affiliated Hospital of Jiangnan University
Eligibility
Sex/Gender
Female
Age
45 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1: The age is between 45 and 60 years old; 2: Body mass index (BMI) between18 and 30kg/?; 3: Improved Kupperman score > 6. 4: American Association of Anesthesiologists (ASA) Grade I ~ II, with good cardiopulmonary function and no obvious surgical contraindications. 5: Female patients who underwent laparoscopic total hysterectomy for the first time in the Affiliated Hospital of Jiangnan University
Exclusion criteria
Exclusion criteria: 1: Contraindications of nerve block: coagulation dysfunction, puncture site infection, deformity or tumor, etc. 2: Complicated with dysfunction of important organs such as heart, liver and kidney. 3: Uncontrolled hypertension or poor blood pressure control 4: Complicated with chronic pain or taking analgesic drugs for a long time 5: Complicated with central nervous system diseases or psychosis 6: Allergic to local anesthesia drugs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HADS (Hospital Anxiety and Depression Scale) score; | — |
Secondary
| Measure | Time frame |
|---|---|
| MMSE (Mini Mental State Examination Scale) score; | — |
Countries
China
Contacts
Public ContactZhang Zhongjun
Affiliated Hospital of Jiangnan University
Outcome results
None listed