Polycystic Ovary Syndrome (PCOS) is characterized by:· Hyperandrogenism (clinical or biochemical)· Ovulatory dysfunction (e.g., oligo-ovulation or anovulation)· Polycystic ovarian morphology on ultrasound· It is frequently associated with insulin resistance, obesity, and metabolic syndrome.
Conditions
Interventions
Letrozole-Only Group (i.e., LE + E(0mg) Group):Estrogen supplementation at 0 mg/day
Letrozole + Estrogen (4 mg/day) Group:Estrogen supplementation at 4 mg/day
Sponsors
Dongguan People's Hospital
Eligibility
Sex/Gender
Female
Age
22 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Aged 22-45 years, meeting the 2018 Chinese diagnostic criteria for Polycystic Ovary Syndrome (PCOS). 2. Diagnosed with ovulatory dysfunction infertility and scheduled for ovulation induction therapy. 3. Normal baseline sex hormone levels (FSH, LH, E2, PRL, T) and thyroid function. 4. Body Mass Index (BMI) >= 18 kg/m², with no severe medical comorbidities (e.g., diabetes, hypertension, history of thrombosis).
Exclusion criteria
Exclusion criteria: 1. Presence of severe comorbidities affecting the cardiovascular, cerebrovascular, hepatic, or renal systems, malignancies, or hematopoietic dysfunction. 2. Uterine abnormalities (e.g., polyps, adhesions, malformations), endometriosis, or hydrosalpinx. 3. Abnormal semen analysis in the male partner, as defined by WHO criteria. 4. Known allergy or hypersensitivity to any of the study medications. 5. Poor compliance, diagnosed psychiatric disorders (including those formally diagnosed by a psychiatrist or psychologist, such as severe anxiety or depression), or inability to communicate effectively. 6. Family history of thrombosis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| clinical pregnancy rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Endometrial thickness on the day of HCG administration;Ovulation Rate;Hormone levels (Estrogen, Progesterone, LH) on the day of hCG administration; | — |
Countries
China
Contacts
Public ContactAihua Wu
Dongguan People's Hospital
Outcome results
None listed