Postoperative Pain, Immunological Status, and Delirium in Patients Following Spinal Tuberculosis Surgery
Conditions
Interventions
Sufentanil group:Postoperative continuous analgesia with Sufentanil.
Oliceridine group:Postoperative continuous analgesia with Oliceridine.
Sponsors
Hebei Chest Hospital
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 60–80 years, regardless of gender, diagnosed with spinal tuberculosis by imaging and pathological examination of lesion specimens, with confirmed exclusion of non-tuberculous mycobacterial infection, and scheduled for elective surgical treatment; 2. ASA physical status I–III; 3. Preoperative Mini-Mental State Examination (MMSE) score >=24; 4. Informed of the study content and objectives, voluntarily participating in the study, and having signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Severe cardiopulmonary dysfunction, hepatic or renal insufficiency (Child-Pugh Class C, estimated glomerular filtration rate [eGFR] 50 mL/day. Known allergy or contraindication to opioid medications (e.g., sufentanil, oliceridine). Pregnancy or lactation. Participation in another clinical trial within 1 month prior to surgery. Cognitive or language impairment that would preclude compliance with study assessments. History of drug or alcohol dependence.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual Analogue Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| S100ß protein and neuron-specific enolase;Postoperative delirium incidence rate;Percentage of CD3+ (cells);Nausea and vomiting, respiratory depression, abdominal distension, constipation, dizziness, pruritus.;CD4+/CD8+ ratio;Percentage of CD4+ (cells);IL-10, IL-6, TNF-a, IFN-? ;Patient's cognitive status at discharge; | — |
Countries
China
Contacts
Public ContactZhao Zijun
Hebei Chest Hospital
Outcome results
None listed