Sepsis
Conditions
Interventions
Test group:The initial infusion rate is [0.025×kg]·ml/h (equivalent to 0.05 g/kg/h for dexmedetomidine and 0.025 mg/kg/h for esmolol). Depending on the patients condition, the infusion rate can be inc
Control group:The infusion rate of 0.9% normal saline was the same as that of the test drug.
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1.Age (>=18 years); 2.Non-mechanical ventilation patients receiving clinical treatment in the ICU at night (after 6pm) for an estimated duration of at least 12h; 3.Meet the diagnostic criteria for sepsis (Sepsis 3.0) (suspected or combined infection and SOFA score >=2);
Exclusion criteria
Exclusion criteria: 1.History of schizophrenia, epilepsy, Parkinson's disease, myasthenia gravis; 2.Inability to communicate due to coma, delirium, severe dementia or language disorders; 3.Stroke, hypoxic encephalopathy, craniocerebral injury or neurosurgical surgery; 4.Patients with a history of hyperthyroidism and pheochromocytoma; 5.Regular (continuous for more than 1 week) use of sedative/bedtime medication, analgesic within the last month; 6.The current left ventricular ejection fraction (left ventricular ejection fraction, LVEF) is less than 30%, or sick sinoatrial node syndrome, severe sinus bradycardia (heart rate 30kg/m^2; 9.Allergy to dexmedetomidine and/or esketamine; 10.Patients who are not suitable for inclusion after the study doctor evaluates the basic condition; 11.Participate in other clinical studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| N2 sleep percentage; | — |
Secondary
| Measure | Time frame |
|---|---|
| Join the group that eveninchanges in sleep structure, including total sleep time, sleep efficiency, sleep fragmentation index, and the duration and percentage of each sleep stage.;Subjective sleep score ;subjective pain scoring ;delirium occurrence ;SOFA score;arterial blood gas lactate levels, the use and dosage of vasoactive drugs, IL-6 and hs-CRP were measured once daily at 20:00.;Non-mechanical ventilation time, mechanical ventilation time (for intubated patients), and ICU stay time.; | — |
Countries
China
Contacts
Public ContactLi Shuangling
The First Hospital of Peking University
Outcome results
None listed