Perioperative neurocognitive impairment
Conditions
Interventions
Ciprofol group:Anesthesia induction is used for ciprofol 0.4-0.6mg/kg, and anesthesia maintenance is ciprofol 4-8/mg/kg/h controlled infusion
Propofol group:Anesthesia induction is used for propofol 1.5-2.5mg/kg, and anesthesia maintenance is propofol 0.8-1.2/mg/kg/h controlled infusion
Sponsors
Shanxi Provincial People's Hospital
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Female patients classified as ASA I–III by the American Society of Anesthesiologists (ASA); 2. Aged 18–80 years; 3. Preoperative Mini-Mental State Examination (MMSE) score >=24; 4. No history of neurological diseases or use of psychiatric medications; 5. Signed informed consent form.
Exclusion criteria
Exclusion criteria: 1.There are serious systemic diseases; 2.Have a history of allergy to drugs used in the institute, alcohol or abuse of sedative and analgesic drugs; 3.Patients with a preoperative 1d simple assessment of the intellectual status scale (MMSE) score of 300 ml or blood transfusion; 5.Those who have severe hypotension during the operation and still improve the poor after using vasoactive drugs more than 3 times; 6.Those who have hypoxemia that is difficult to correct during the operation; 7.Patients who cannot complete or refuse the whole process of testing for various reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mini-Mental State Examination Score;Montreal Cognitive Assessment Score;Self-Rating Depression Scale Score; | — |
Countries
China
Contacts
Public ContactCheng Yan
Shanxi Provincial People's Hospital
Outcome results
None listed