Clonorchiasis
Conditions
Interventions
Tribendimidine Group:Tribendimidine: 0.4 g once daily (qd) for 3 days.
Albendazole Group:Albendazole: 10 mg/kg once daily (qd) for 7 days.
Praziquantel Group:Praziquantel: 25 mg/kg, three times a day (tid) for 2 days
Sponsors
The People’s Hospital of Guangxi Zhuang Autonomous Region
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged 18 years or older, regardless of gender. 2. Conform to the definitive diagnosis of clonorchiasis as per the latest editions of Infectious Diseases and the Expert Consensus on the Diagnosis and Treatment of Foodborne Parasitic Diseases (2023), confirmed by the presence of eggs or adult worms in stool examination or bile drainage fluid. 3. Patient agrees to the study plan and provides written informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with a known allergy or hypersensitivity to albendazole, praziquantel, or tribendimidine. 2. Patients with severe hepatic, renal, or cardiac insufficiency, or active ulcer disease. 3. Patients with a confirmed diagnosis of concurrent cerebral cysticercosis by clinical or imaging examination; 4. Patients with a confirmed diagnosis of concurrent ocular cysticercosis by clinical or imaging examination. 5. Patients with gallstones or biliary tract obstruction as indicated by abdominal ultrasonography. 6. Pregnant or lactating women, and women who are planning a pregnancy. 7. Patients who are planning to relocate, refuse to continue participation, or are unable to complete the protocol-defined follow-up for any other reason.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Re-examination of stool for Clonorchis sinensis eggs and calculation of the egg reduction rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hematological parameters (complete blood count, liver function biochemical tests).;Hepatobiliary ultrasound (to assess for findings indicative of clonorchiasis infection, etc.).; | — |
Countries
China
Contacts
Public ContactZhang Li
The People’s Hospital of Guangxi Zhuang Autonomous Region
Outcome results
None listed