None listed
Conditions
Interventions
Intervention group:Oliceridine 0.2 mg/kg + flurbiprofen axetil 200 mg + tropisetron 10 mg, diluted to 100 mL with 0.9% sodium chloride injection.
Control group:Sufentanil 2 µg/kg + flurbiprofen axetil 200 mg + tropisetron 10 mg, diluted to 100 mL with 0.9% sodium chloride injection.
Sponsors
The First Affiliated Hospital of Xiamen University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 65 years. 2. Scheduled for elective gynecological laparoscopic surgery, with an anticipated operative duration of less than 3 hours. 3. American Society of Anesthesiologists physical status classification of I to III. 4. Body mass index ranging from 18 kg/m^2 to 26 kg/m^2.
Exclusion criteria
Exclusion criteria: 1. Patients with chronic pain requiring long-term use of analgesics or psychotropic drugs, or with alcohol abuse; 2.Known allergy or contraindications to any of the study drugs; 3. Patients with shock, psychiatric disorders, or cognitive dysfunction that would impair cooperation; 4. Acute or chronic bronchial asthma; sleep apnea syndrome; 5. Prolongation of the corrected QT (QTc) interval on electrocardiogram.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The total incidence of PONV; | — |
Secondary
| Measure | Time frame |
|---|---|
| Resting and dynamic NRS pain scores at 48 hours postoperatively;Time to first PCA demand;Ramsay Sedation Scale (RSS) Score;QoR-15 Score;Time to first defecation/flatus; | — |
Countries
China
Contacts
Public ContactChen Zhenyi
The First Affiliated Hospital of Xiamen University
Outcome results
None listed