Full-term singleton primiparous women undergoing vaginal delivery
Conditions
Interventions
Control group (Normal saline group):Placebo (normal saline)
Trial group (Esketamine group):Intravenous administration of esketamine (0.2 mg/kg) after fetal delivery.
Sponsors
Affiliated hangzhou first people's hospital, zhejiang university school of medicine
Eligibility
Sex/Gender
Female
Age
22 Years to 35 Years
Inclusion criteria
Inclusion criteria: 1. Age between 22 and 35 years (22 < age < 35); 2. Primiparous women with term, singleton vaginal delivery; 3. ASA physical status classification I–II; 4. Educational level of high school or higher; 5. Written informed consent signed by the patient or the patient’s family member; 6. Edinburgh Postnatal Depression Scale (EPDS) score = 9.
Exclusion criteria
Exclusion criteria: 1.There are contraindications for vaginal delivery; 2.Has a history of mental illness and personality disorders, is unable to communicate normally and has low cognitive abilities; 3.There are contraindications for intraspinal anesthesia such as inability to cooperate, abnormal coagulation function, low platelet count, and spinal deformity; 4.There are severe preeclampsia, respiratory insufficiency and other serious heart and lung diseases; 5.Any contraindications to ketamine or esketamine, such as refractory hypertension, severe cardiovascular disease or hyperthyroidism; 6.ASA classification grade III or above; 7.Due to fetal distress in the uterus, a cesarean section was performed;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of PPD at 7 days and 42 days postpartum; | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse reactions;numerical rating scale (NRS) scoring;Depression relief and total EPDS score at 7 and 42 days postpartum;Mean change in EPDS score from baseline; | — |
Countries
China
Contacts
Public ContactLei Weiping
Affiliated Hangzhou First People’s Hospital
Outcome results
None listed